Standard AOD-9604 Dosing Protocol Subcutaneous Injection Dosing: Beginner: 250 mcg per dose, once daily Intermediate: 300-400 mcg per dose, once daily or divided into two doses Advanced: 500 mcg per dose, once daily or 250 mcg twice daily Oral Administration Dosing (if using oral formulation): Standard: 1-2 mg per dose, once daily on empty stomach Higher protocols: Up to 5-10 mg daily, as studied in clinical trials Frequency: Once daily (morning preferred) or twice daily (morning and early afternoon) Timing: Best administered on an empty stomach, typically upon waking or before exercise Cycle Length: 12-16 weeks for initial assessment, with potential for longer protocols based on response Off Cycle: 4-8 weeks between cycles, though not strictly required based on current research Note: Start at the lower end of the dosing range to assess individual tolerance
Description 5-Amino-1MQ, or 5-amino-1-methylquinolinium, is a novel small molecule compound that functions as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme predominantly active in adipose tissue
Every time we eat, GLP-1 is released in the body to help regulate blood sugar levels and trigger the pancreas to release insulin
"MOTS-c can significantly enhance physical performance in young, middle-age, and old mice." Reynolds et al., Nature Communications , 2021 [3] The ceiling on all of this is the same ceiling every mitochondrial peptide hits: the outcome data is rodent data
But understanding *why* requires a deeper look at both compounds
The dosages seem to be more along the lines of 150mcg-300mcg whereas many of the pill forms are 25mg-50mg
